High-purity cucurbit[n]uril series and highly water-soluble modified cucurbituril products with custom synthesis and technical collaboration
Complete product line with high purity, exceeding industry standards
Focused on supramolecular materials, with deep insight into research needs
Professional custom synthesis services. Technical collaboration available.
Representative cucurbituril products across standard and derivative categories
![Cucurbit[5]uril](https://material-image.wanwang.xin/1708783130487998/public/e8bbfad3-6e7d-4e7c-8457-502f34f3b85c.png)
CAS:259886-49-2
Purity: ≥98%
Bulk pricing available
![Symmetrical tetramethyl cucurbit[6]uril](https://material-image.wanwang.xin/1708783130487998/public/a1e443a3-b4c7-4eb3-a50e-7a471a507817.png)
CAS:Available upon request
Purity: ≥98%
Bulk pricing available
![Cyclohexyl cucurbit[5]uril](https://material-image.wanwang.xin/1708783130487998/public/f4f97a84-3f6f-4da1-b666-52b5c7cb9ed6.png)
CAS:Available upon request
Purity: ≥98%
Bulk pricing available
Cucurbit[n]urils are barrel-shaped macrocycles composed of glycoluril units linked by methylene bridges. They feature electron-rich, carbonyl-fringed portals at both rims. Their rigid cavity offers size selectivity, while the hydrophobic walls and ion–dipole interactions at the portals provide the driving force for binding. This combination gives cucurbit[n]urils a well-defined role in host–guest chemistry, drug delivery, sensing, and supramolecular materials.
Cucurbit[n]urils are barrel-shaped macrocycles composed of n glycoluril units bridged by methylene groups, with the general formula (C6H6N4O2)n.. The framework is conformationally rigid, so size selectivity arises from geometric cavity–guest complementarity rather than induced fit.
The cavity wall is formed by glycoluril C–H groups and bridging methylenes, making it distinctly hydrophobic. In water, guest entry displaces high-energy cavity water, so the hydrophobic effect dominates the binding free energy.
Each rim carries n carbonyl groups pointing into the portal. The partially negative oxygens provide strong ion–dipole attraction for cationic guests and hydrogen bonding to N–H / O–H donors—the defining feature that distinguishes cucurbiturils from other macrocycles.
With well-matched guests, CB[7] achieves association constants of 10⁹–10¹² M⁻¹ with ferrocene and adamantylamine derivatives—orders of magnitude higher than typical cyclodextrin systems—ensuring complex stability even at low working concentrations.
The cucurbituril backbone is stable against strong acids, common organic solvents, and heat. It withstands chromatography, catalytic reactions, and materials processing, and can be stored for long periods.
Numerous studies report low cytotoxicity for CB[7] in cell experiments, making it widely used for aqueous drug solubilization, controlled release, fluorescent probing, and biomolecular recognition. Compatibility should still be verified in each specific system.
